Gene mutation blamed for lower breast cancer cure rates in Chinrubber wristbands for eventsa than in the West

You Don"t Want To Miss The Sunburn Music Festival Thinking of hosting your very own workshop or seminar? No matter if you imagine hosting prospective new clients for the weekend, customers for a couple of hours, or associates over a breakfast style workshop, lets make sure that this year is the year you recognize that dream! Planning and holding a seminar, live training session or workshop is not nearly as difficult as you first might expect. In this article I am going to share with you the five tricks to a perfect workshop. WHO ARE YOU GOING TO INVITE? Your guest list will be the determining factor in almost every decision that you have to make while planning your party. If you have to rent a location for your event you will need one large enough to hold all of your guests. The number of people you have will determine the amount of food, how many chairs and the number of gift bags to prepare if that will be part of you event wristbands. So sit down and make a list of potential guests. Right now it"s a whirlwind of excitement for me. I"m painting sport wristbands all the time and have ideas come to mind This has been the longest stretch of having my artist mojo in... well forever. I hope the future brings new exhibit opportunities, increase in orders for custom work, I hope for a few sales, and I can"t wait to see what I learn. Hopefully I will be able to show on a smaller scale and maybe even put on a show myself. The festival will start at 4:00 p.m. on Sunday and will last for most of the day. There will be a long lineup of live bands, as well as a live radio broadcast from the top comedy talk radio shows on iTunes, Red Bar Radio and Wreckless Media Radio. Those who attend will have a chance to get on the air. The Agricenter is hosting the Delta Fair and festival wristbands on August 31-September 9. You will know you are there when you smell the funnel cakes and corn dogs that give you the full fair food experience. As you enter the park purchase a wrist band so that you can enjoy everything that the fair has to offer. Browse through the many arts and crafts vendors. There is a ride for everyone to enjoy and there is a kid zone that offers fun for everyone to enjoy with the kids. You will be amazed by all of the roaming fair entertainers and taking aback when you see two people eating away at watermelons for a prize. At the end of the evening make sure to stop and take in the lights of the fair. This is definitely the top pick of things to do for Labor Day Weekend. What"s cool is that these young entrepeneurs have self-orchestrated this entire tour themselves along with the help and support of friends who have reached out to the duo. Cat and Stasia have continued to grow as individuals through their artistry; gaining nothing but experience from the project. These events are fun and exciting. I personally will be going to Delta Fair and Music Festival so that I can take my daughter to enjoy all of the rides and see all of the vendors, I am a sucker for good crafts and end up spending a bundle. On that note, I hope this will guide you in some ideas for the weekend. Labor Day signifies the end of summer and there is no need to let it go to waste.

BEIJING -- Chinese researchers claim, based on a three-year research, that gene mutation shall be blamed for the lower breast cancer cure rate in China than in the West, as it cripples the effect of a classical drug for treatment.

The mutation in a liver enzyme among East Asian people may severely impair the conversion of tamoxifen (TAM), a standard drug for breast cancer post-operation therapy in most cases, said Xu Binghe, a professor at the Cancer Hospital with Chinese Academy of Medical Sciences.

About 75 percent of breast cancer patients in China have estrogen receptors (ERs) expressed in their tumors. Nurtured by estrogen, a female hormone, the receptors can facilitate the growth of tumors, leading to their metastasis and recurrence, so these patients usually receive endocrine treatment after their operation, said Xu, an oncologist on breast cancer for more than 30 years.

"Globally, TAM is a classic drug for this type of cancer and has been used in clinical treatment for nearly half a century since the 1970s," Xu said.

According to him, TAM, a small molecule compound, can block the binding of human estrogen to tumor receptors.

"TAM looks so similar to estrogen that it can confuse the receptors, which then unites with the drugs and rejects the real estrogen," said Xu. "So to speak, TAM is like a fake key that can match the "lock" of tumors, and estrogen, the real key, instead cannot open the "door" anymore as it shall not fit in a blocked "keyhole.""

ER-positive breast cancer patients usually need to take TAM for five to 10 years after surgery. The drug has helped cut down the recurrence rate by half and the death rate by more than 30 percent. TAM is also very economical, costing less than one yuan (about 15 cents in U.S. dollar term) a day. The drug, with its effectiveness and low cost, has been enlisted in both international and domestic guidelines for breast cancer treatment.

"However, in our practice, we feel that it is not as effective on Chinese patients as it is on Westerners," Xu said. Although the overall survival rate of breast cancer patients in China has improved dramatically in recent years, it is still seven to 10 percentage points lower than that in the United States.

A special enzyme named CYP2D6 in the liver, which plays a key role in converting TAM into active and valid ingredients, has caused attention among Xu and his coworkers on the team. It has more than 100 types of gene mutations, and CYP2D6*10 is the most common polymorphism among Asian populations.

"Is this mutation crippling the effectiveness of the drug?" This question has emerged from day-to-day treatment and prompted Xu"s team to conduct a retrospective study of nearly 1,000 patients who have been treated at their hospital.

Testing their blood samples revealed that 20 percent of the patients have the CYP2D6*10 genotype with both chromosomes mutative. These patients have a lower five-year survival rate and a higher recurrence rate than others.

"It indicates that the gene mutation obviously impacts the conversion of TAM, which lowers the drug"s effectiveness to only 1 percent of the expected efficacy. In other words, to achieve the effect of one pill for ordinary patients, these cancer sufferers have to take 100 pills," said Ma Fei, a core researcher on Xu"s team from the Cancer Hospital.

The researchers also found that the effect of toremifene and aromatase inhibitors, alternatives to TAM, are not affected by the gene mutation in the CYP2D6 enzyme.

"Since alternative drugs are more expensive, there has been a long-time misunderstanding that patients who use them are more wealthy and have access to better overall medical conditions, leading to a lower cancer recurrence rate among them," Ma said. "It seems now that the gene mutation should shoulder the blame."

He noted that this study is very important for all East Asian populations, as the gene mutation happens in one in every five people while it is quite rare in Westerners.

"We can"t expect experts in America and European countries to do the research, as they don"t encounter the problem. The difficulties that China has faced can only be solved by ourselves," Ma said.

The results of the serial researches by the team were published twice in the International Journal of Cancer, the official journal of the Union for International Cancer Control, and the latest was selected as a cover article in November.

Xu and his team will, for the next step, study the feasibility of multiple alternative therapies for patients with the above gene mutation, aiming to modify and improve the treatment guidelines through more rigorous clinical research and to improve the breast cancer cure rate in China.


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